Biochemistry

The purpose I share my medical syllabus during my era is to help me know the topic should I revise during my free time to improve my medical knowledge and to give an idea for future medical students about the topic they would learn in medical school.

Topic of Biochemistry discussed during my time in Medical School:

A. LECTURE:

1. 1st semester:

a. Basics Science in Medicine (General Knowledge):

- Molecular of life

- Genetic information: DNA structure, replication-transcription-translation in protein synthesis, gene regulation and expression, cell cycle, protein synthesis inhibitor, mutation and its effect

- Organisation of cell: Cell membrane, membrane transport

- Communication of cell: Molecular endocrinology

- Enzyme: Enzyme and co-enzyme, molecular mechanism of enzyme reaction, enzyme kinetic

- Biochemistry reaction: Biological oxidation, TCA cycle and chain of respiration

- Isolation of DNA

2. 2nd semester:

a. Metabolism System:

- Metabolism reaction pathways: Carbohydrate metabolism, lipid metabolism, amino acid metabolism, nucleotide metabolism, interaction of multiple metabolic reaction pathways, metabolites and end products in blood

- Controlling hormones in metabolism and food intake: Hormones in regulation of carbohydrate, lipid and protein metabolism (insulin, glucagon, thyroid hormone)

b. Hematological and Immunological System:

- Element of blood: Hemoglobin

3. 3rd semester:

a. Reproductive System:

- Biosynthesis and transportation of female reproductive hormones: Hypothalamus, pituitary, ovarian hormones, testosterone hormone

- Biosynthesis and transportation of male reproductive hormones (testosterone, dihydrotestosterone, estradiol)

- Malignancy of female reproductive organ: Molecular biology of carcinoma (oncogene and tumor suppressor gene, metastatic tumor, angiogenesis)

b. Growth and Development:

- Factor that affecting growth and development of children: Hormonal and growth factor in children's growth and development (growth hormone, IGF-1, IGF-2, EGF, insulin, thyroid and etc.)

4. 4th semester:

a. Dermatomusculoskeletal System:

- Biochemistry of tissue: Mineralization of bone, extracellular matrix (structural protein, specific protein, proteoglycan)

b. Cardiovascular System:

- Structure and feature of cardiac muscle: Sarcoplasm

- Actin-myosin-ATP interaction in contraction of cardiac cell

- Function of troponin and tropomyosin system

- Function of calcium ion and creatinine phosphate in contraction of cardiac cell

c. Respiratory System:

- Acid-base equilibrium: Definition of pH (Handersen Hasselbach equation), function of buffer, function of hemoglobin in maintaining acid-base equilibrium

5. 5th semester:

a. Gastrointestinal System:

- Biochemistry in digestive system

b. Special Senses System:

- Neurotransmitter of eye

6. 7th semester:

a. Family Medicine:

- Prenatal care: Genetic counselling (Pedigree analysis, genetic assessment, history taking-physical examination-diagnostic in genetic counselling

- Closed bloodline marriage and genetic counselling aspect 

b. Elective (Viral-Oncogene):

- Oncogenes and tumor suppressor genes: Pro-oncogene,tumor suppressor gene, oncogene, type of mutation in oncogene, virus role in mutation, oncogene product

- Cellular signalling: Intracellular signalling pathway to oncogene

B. LABORATORY:

1. 1st semester:

a. Basic Science in Medicine (General Knowledge):

- Isolation of DNA

- Enzyme activity

2. 2nd semester:

a. Metabolism System:

- Blood sugar level analysis

- Total blood protein level analysis

- Blood urea level analysis

3. 3rd semester:

a. Reproductive System:

- Urine protein test

4. 4th semester:

a. Dermatomusculoskeletal System:

- Determining creatinine level

5. 5th semester:

a. Genitourinary System:

- Detection of blood in urine

b. Gastrointestinal System:

- Bilirubin (laboratory topic)

6. 7th semester:

a. Elective (Viral-Oncogene):

- Polymerase Chain Reaction (PCR)

C. TUTORIAL:

1. 1st semester:

a. Basic Science in Medicine (Mechanisms of Disease and Physiological Responses):

- Immunodeficiency

2. 6th semester:

a. Brain and Mind System:

- Formation and function of cerebrospinal fluid (CSF)

*This medical syllabus copied and edited from 2 manual books for 1st semester medical student, 2 manual books for 2nd semester medical student, 2 manual books for 3rd semester medical student, 3 manual books for 4th semester medical student, 3 manual books for 5th semester medical student, 1 manual book for 6th semester medical student and 2 manual books for 7th semester medical student from my university during my era. 
**The topic currently discussed in my university may different from this syllabus due to progression of medical knowledge and improvement of quality for medical syllabus based on my university assessment.