Saturday, April 25, 2020

Pharmacology

The purpose I share my medical syllabus during my era is to help me know the topic should I revise during my free time to improve my medical knowledge and to give an idea for future medical students about the topic they would learn in medical school.

Topic of Pharmacology discussed during my time in Medical School:

A. LECTURE:
1. 1st semester:
a. Basic Science in Medicine (Diagnosis and Therapy/ Intervention at Cellular/ Molecular Level):
- Pharmacotherapy: Basic principle of Pharmacology, Basic principle of Pharmacokinetic, Basic principle of Pharmacodynamic, Pharmacogenetic (Pharmocogenomic), drug interaction
- Resistancy: Basic Principle of resistance and mechanism of resistancy

2. 2nd semester:
a. Control System:
- Basic of Pharmacology: Drugs and its problems, absorption, distribution, bio-transformation, excretion, dosage-response relationship, clinical pharmacokinetic, drug level monitoring, non-therapeutic drug effect, factors that influencing pharmacology of drug, pharmacokinetic interaction, pharmacodynamic interaction, cascade of drug transcription, pharmacoeconomy, drug prescription matters
- Pharmacology of central nervous system
- Pharmacology of peripheral nervous system
- Pharmacology of endocrine system
b. Metabolism System:
- Pharmacology of the endocrine pancreas
- Pharmacology of thyroid gland
- Pharmacology of adrenal cortex
- Pharmacology of the hypothalamus and pituitary gland
c. Hematological and Immunological System:
- Medications used in anemia: Oral iron supplementation and hematopoietic growth factors
- Medications used in bleeding and coagulation disorder: Anti-coagulation agent, fibrinolysis agent, anti-platelet agent, anti-thrombus agents, anti-hemorrhagic agent
- Medication that cause hemostasis disturbance
- Medications used in blood malignancy: Cytostatic drugs
- Immunopharmacology: Immunomodulator (basic concept of immunomodulator agents, antibodies as immuno-suppressive drugs, immunomodulating agents-cytokines), medications that (may) cause allergic and hypersensitivity reaction (NSAIDs, Antibiotic, etc.)

3. 3rd semester:
a. Reproductive System:
- Medications in pregnancy
- Uterotonic and tocolytic
- Medications in lactation (breastfeeding)
- Pharmacokinetic and Pharmacodynamic of female hormonal contraception
b. Growth and Development:
- Biological and physical requirement that effecting growth and development of infant and toddler: Medications affecting growth and development, exposure of active substance that affecting growth and development

4. 4th semester:
a. Dermatomusculoskeletal System:
- Pharmacology of leprosy medication
- Pharmacology of fungal skin infection
- Pharmacology of skin disease: Topical agents, corticosteroids
- Somatic sensation: Pharmacology of painkiller medication for dermato-musculo-skeletal system
- Bone metabolism and drugs used in bone disorders
b. Cardiovascular System:
- Pharmacology of anti-hyperlipidemia agent
- Pharmacology of vasolidator, anti-angina and anti-coagulant drugs
- Pharmacology of anti-hypertensive agents
- Pharmacology of anti-arrhythmia agents
- Pharmacology of cardiotonic, heart failure medication and diuretic
c. Respiratory System:
- Pharmacology of anti-tuberculosis medication: Isoniazide, Rifampin, Ethambutol, Pyrazinamide, Streptomycin, second-line drugs for tuberculosis (aminosalicylic acid, kanamycin, amikacin, etc.)
- Pharmacology of cough medication and asthmatic drug


5. 5th semester:
a. Genitourinary System:
- Pharmacology of Diuretic and anti-diuretic agent
- Medication that alter pH of urine 
- Pharmacological aspect of benign prostate hypertrophy (BPH) medication
b. Gastrointestinal System:
- Pharmacology of anti-emetic medication, prokinetic of the bowel movement, anti-spasmodic, anti-diarrhea medication
- Pharmacology of cholekinetic and choleretic 
- Pharmacology of bile acid therapy for gallstone
- Pharmacology of peptic ulcer
- Medication used in irritable bowel syndrome (IBS)
- Substance of medication that influencing digestion
- Drugs used to treat variceal hemorrhage
- Pharmacology of laxative (bulk forming laxative, osmotic laxative, stimulant laxative), stool surfactant (softener)
- Prescription in digestive system cases
- Drugs interaction of polypharmacy prescription in digestive system
- Route of entry for medication used in digestive system
c. Special Senses System:
- Medications that influencing visual acuity
- Medication that influencing hearing
- Pharmacology of nasal decongestant
- Medication that influencing smell
- Medication that influencing taste

6. 6th semester:
a. Brain and Mind System:
- Pharmacology of central nervous system: Ionized voltage-gated canal and ligand-gated  in neuronal membrane, drug mechanism in modulation of synaps transmission, excitatory of central neurotransmitter
- Pharmacology of analgesic: Pharmacology of opioid analgesic, pharmacology of opioid antagonist receptor, pharmacology of non-opioid analgesic
- Pharmacology of medication used in extrapyramidal disorder
- Pharmacology of anti epilepsy agent
- Pharmacology of medication used in headache and vertigo
- Pharmacology of narcotic and addictive substance (Narcotic-Alcohol-Psychotropic-Addictive substance)
- Pharmacology of anti-psychotic drug
- Basic pharmacology  of lithium and mood stabilizer drug
- Basic pharmacology of antidepressant
- Side effect of psychoactive drug
b. Emergency Medicine:
- Pharmacology in emergency cases or critical illness: Management of drug withdrawal, pharmacological therapy in emergency cases (dopamine, dobutamine, adrenaline, digoxine, amiodarone, anticonvulsants, medication used in hypertensive crisis, morphine, pethidine)
- Pharmacological therapy for drugs or substance poisoning

7. 7th semester:
a. Tropical Medicine:
- Medication used in tropical infection and disease: Chemotherapy drugs, antibiotics (betalactam, chloramphenicole, tetracycline, aminoglycoside, macrolides, quinolone, sulphate derivative), antivirus, antifungal, antelminthic, antiprotozoan, antimalaria
b. Family Medicine:
- Pharmacoeconomics: Pharmacoeconomics consider: cost-benefit, cost-utility, cost-effectiveness, Rational in prescription, cascade in prescription 
- National drugs policy, registration of national essential drugs, legislation of over the counter (OTC) medication 
- Determination of popular drug (P-drug), ambulatory drug therapy 
- Recommendation for prescription in children: special considerations, adverse drug reactions, therapeutic drug monitoring 
- Recommendation for prescription in geriatric: special considerations, adverse drug reactions, therapeutic drug monitoring 
- Traditional medicine: Definition, classification of traditional medicine in Indonesia, pharmacological aspect of traditional medicine, development of traditional medicine, special attention to traditional medicine
- Benefit of number need to treat (NNT) and number need to harm (NNH) in prescription of medication
c. Elective (Tropical Infectious Disease):
- Pharmacological aspect of anti malaria
- Pharmacological aspect of anti-retro viral drugs
d. Elective (Viral-Oncogene):
- Pharmacology of anticancer drugs
e. Basic Biomedical Science in Elective:
- Dosage-response relationship
- Route of drugs administration
- Non therapeutic effect
- Pharmacokinetic interaction
- Pharmacodynamic interaction
- Pharmacology of sympathetic autonomic nervous system and relation to clinical signs and symptoms
- Pharmacology of parasympathetic autonomic nervous system and relation to clinical signs and symptoms
- Factor that affecting pharmacology of drug


B. LABORATORY:
1. 2nd semester:
a. Control System:
- Posology of drug
- Writing technique of drug transcription
- Unmixed drugs interaction
b. Metabolism System:
- Metabolism of salicylic drug
- Calculation of drug dosage

2. 3rd semester:
a. Reproductive System:
- Detection of sulfonamide in urine
- Drug interaction for medication used in pregnancy and lactation, genital and reproductive matter
b. Growth and Development:
- Prescription of drugs and compounding drugs in peadiatric
- Drug interaction in polypharmacy drug prescription in paediatric

3. 4th semester:
a. Dermatomusculoskeletal System:
- Posology of topical medication and drug interaction of skin disease medication
- Effect of histamin and antihistamin in dermato-musculo-skeletal system
- Effect of local anesthetic drug in reducing pain effect in musculo-skeletal system
b. Cardiovascular System:
- Posology of drugs used in cardiovascular disease
- Drug interaction of polypharmacy prescription in cardiovascular cases
- Caffeine's effect in cardiovascular system
- Beta-blocker effect in cardiovascular system
c. Respiratory System:
- Pharmacology of drug used in respiratory system cases
- Posology of drugs used in respiratory disease
- Drug interaction of polypharmacy drug prescription in respiratory cases

4. 5th semester:
a. Genitourinary System:
- Medication that alter pH of urine
- Posology of drug used in genitourinary system cases
- Drugs interaction of polypharmacy drug prescription in genitourinary system
- Pharmacology of medication used in genitourinary system cases
b. Gastrointestinal System:
- Posology and route of entry for medication used in digestive system
c. Special Senses System:
- Agonis and supra agonis effect of medication used in ocular system
- Drugs interaction of polypharmacy drug prescription in eye and ENT cases

5. 7th semester:
a. Basic Biomedical Science in Elective:
- Drugs and therapeutic classes of drugs
- Calculation of dosage in pediatric drug
- Popular drug (P-drug) simulation from cases in hospital ward
- Prescription technique of ready-made drug and concoction drug



*This medical syllabus copied and edited from 1 manual book for 1st semester medical student, 3 manual books for 2nd semester medical student, 2 manual books for 3rd semester medical student, 3 manual books for 4th semester medical student, 3 manual books for 5th semester medical student, 2 manual books for 6th semester medical student and 2 manual books for 7th semester medical student from my university during my era. 
**The topic currently discussed in my university may different from this syllabus due to progression of medical knowledge and improvement of quality for medical syllabus based on my university assessment.

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